Antibodies

This moderated forum is to support the needs of patients with stage IV melanoma, as well as to answer questions about treatment options and what to expect.
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msue5
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Antibodies

Post by msue5 » Sun Apr 09, 2017 9:11 am

I thought I read somewhere that a lot of times antibodies are negative with Immune related adverse effects. Did anyone have experience or remember reading about this.
Mary Sue

Catherine Poole
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Re: Antibodies

Post by Catherine Poole » Fri Apr 14, 2017 6:57 am

Catherine M. Poole, President/Founder
Melanoma International Foundation

CareForMelanoma
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Re: Antibodies

Post by CareForMelanoma » Wed Jul 25, 2018 6:32 pm

Although using immunotherapy to treat melanoma often results in fewer side effects that are less problamatic than those associated with other forms of cancer treatment, some side effects still can occur, and some can be severe. Not everyone will experience the same side effects with immunotherapy, and some people may not experience any side effects at all. Symptoms can vary in severity and differ according to the type of immunotherapy

Immune-mediated adverse reactions have not been a commonly reported side effect of immunotherapy, but they can occur with certain types of immunotherapy medications.

Some side effects may include:
1)Fatigue - Fatigue is the most common side effect reported in several immunotherapies. Fatigue and exhaustion are often found in the class of therapies known as checkpoint inhibitors, cytokines and oncolytic virus therapy.

2)Flu Symptoms- Flu-like symptoms, such as fever, chills, aches, headache, drowsiness, nausea, vomiting, loss of appetite and low blood cell counts, can occur if your treatment includes cytokines or oncolytic virus therapy. These symptoms can range from mild to severe.

3) Diarrhea- a common side effect with the checkpoint inhibitor class of immunotherapies for melanoma, specifically PD-1 and CTLA-4 inhibitors.

4) Mild skin reactions- this includes things like bumpy or itchy red rashes. These reactions are some of the most common side effects of checkpoint inhibitors.


Useful resources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609598/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725414/
http://www.genetex.com/Web/News/Tumor-a ... tigens-345
https://www.cancer.org/cancer/melanoma- ... erapy.html

Hope this helps!
Pat

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