I would ask the doctor about the blisters. Not sure what that would be caused by or which drug may be causing that. I would get in touch with Dr. Infante’s group at Sarah Cannon in Nashville, TN, they do nothing but research trials and have a lot for melanoma there. Look at our list under Web Resources for other centers. There are some NRAS trials, one by Novartis I know of. Also the PDL is popping up at different locations and still a few PD1 trials. All promising. I would definitely have a “Plan B” lined up!