Hello Catherine. My question for you with regard to the MK3475. My husbands original BRAF mutation for V600 came back negative however another genetic study revealed a mutation in a different area on the BRAF gene called BRAF L597Q (sub clonal). Does that mean he would have to try a BRAF or MEK inhibitor prior to being eligible for the Merck EAP and if so are they FDA approved or clinical trials. He is receiving IMRT and arc radiation now on face and sinus and is scheduled for 2nd Yervoy infusion on April 2. Also is this something you wait for or start registering for in advance in case the Yervoy doesn’t work Thank you.