I’m so sorry you are having to go through this. I wish I had specific information to treatments available in Spain but unfortunately I do not. Do you know what dose of Ipi your husband received? While you continue to look for a treatment or hope for PD-1 treatment to become available have you thought about trying a much reduced infusion of Ipi. My understanding is the High does Ipi is considered to be 10mg/Kg and the low dose is considered 3mg/Kg. Maybe you could see if they would try 1 or 2 mg/kg. It seems like your husband is very sensitive to the drug so maybe he doesn’t need as much as most people to get benefit. This is not the best option but one you may want to consider if other treatments do not become available. I’m hoping Catherine has some better options available to you. Best of luck to you.