Home Forums Melanoma Diagnosis: Stage IV A few openings in a phase I PD I trial

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  • #20565
    Catherine Poole
    Keymaster

    Please check here for possible openings. We don’t know much about this PD1, but it could be promising: http://clinicaltrials.gov/ct2/show/NCT01352884?term=nct+01352884&rank=1

    #56075
    NYKaren
    Participant

    Thanks for posting this, Catherine. Is it my imagination, or does this trial seem to be less restrictive? The issues that stand in my way w/Merck & BMS are measurable disease, measurable disease on prior-irradiated skin, prior Remicade use (don’t remember if that one is BMS or Merck). This is SO frustrating!

    thanks,

    karen

    #56076
    Catherine Poole
    Keymaster

    It is less restrictive, because it is phase I, just figuring out dosage, no true idea of efficacy yet.

    #56077
    LynnLuc
    Participant

    This is my anti pd 1 trial-

    Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 (BMS-936558) and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IV Melanoma

    http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#EntryCriteria_CDR0000682183

    There is NO concurrent use of steroids like Remicade…• At least 2 weeks since prior immunosuppressive doses of systemic medications, such as steroids or absorbed topical steroids (doses > 10 mg/day prednisone or equivalent)

    Anti PD 1 helps keep the bodys immune system in overdrive and would defeat the purpose. I know I had some rashy hive like thing on my hands for two months, probably unrelated to the trial, and the derm doc rx’ed steroids, but my oncologist ( Dr Weber) found out before I started to take it and said no way…the rash eventually healed without the use of it.

    #56078
    LucyG
    Participant

    Claritin helps me with the rash I get from the chemo meds I take.

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