Home Forums Melanoma Diagnosis: Stage IV Advice Sought Phase 1 Trial vs Carbo Taxol

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  • #21114
    jnfife
    Participant

    Hello,

    I am advanced stage 4 and have had 2 surgeries, 3 chemos (Ipi,Zelboraf, Temodar) and radiation. Multiple tumors primarily in my abdomen (some are very large) – my abdomen is quite large because of these huge tumors. I also have edema pretty bad (legs, feet, abdomen). I’ve been presented with two options:

    1) Carbo Taxol (Carboplatin and Paclitaxel) chemo infusions (combination drug therapy)

    or

    2) Phase 1 Trial – Study of oral LKG974 for patients with malignancies depending on Wnt ligands (Novartis) at Karmanos Cancer Center Detroit, Michigan

    I’ve done some research on Carbo Taxol and have some sense of its response rate, but the Wnt Trial is very new and I cannot find any info on this, beyond the consent form.

    Has anybody had any experience with either of these drugs and could share an opinion or some experience. I know there are many very knowledgeable people on this forum and any thoughts or comments would be most appreciated. Is a trial always better than a standard treatment? I’m unsure which way to go.

    Thanks

    Jim

    Windsor, Ontario

    #59691
    Catherine Poole
    Keymaster

    Jim,

    Can’t find much on this drug. Carbo-taxol doesn’t have a great response rate with melanoma. Are you BRAF positive? Have you looked at the immuno-therapies? I would go with something better known with your current status. Are you paying out of pocket too?

    #59692
    kylez
    Participant

    The drug name is actual LGK974 (not LKG…). Nonetheless there’s not much on the web about it and melanoma. The trial is http://clinicaltrials.gov/ct2/show/NCT01351103?term=lgk974&rank=1” class=”bbcode_url”>http://clinicaltrials.gov/ct2/show/NCT01351103?term=lgk974&rank=1. It’s a “porcupine inhibitor” from Novartis with phase I for melanoma and lobular breast cancer.

    #59693
    Catherine Poole
    Keymaster

    Yes, I read that. Phase I is just safety, so no results yet. I’m not sure what porcupine means here.. But there wasn’t any further information on it.

    #59694
    jnfife
    Participant

    Thanks for your comments.

    Catherine,

    Yes I am BRaf + and I took Zelboraf for about three months before tumors started growing and spreading again so I stopped. At Karmanos the sponsor is paying for drug and some tests, but other stuff like Bloodwork I will need to pay out of pocket. We are still discussing CT scans, if I can have them done in Canada then I’m covered there too. But I will need to bring the CDs with results to Karmanos each time. If I have to pay for scans then I will, but I want to ensure I’m on the best path. Didn’t sound too positive on Carbo-taxol.

    Do you have any further suggestion? You mentioned immunotherapy?

    Thanks for any and all input,

    Jim

    #59695
    Anonymous
    Guest

    The standard chemos typically do not have a very high response rate. Carbo Taxol did not work for Rachel.

    The trial you mentioned might target a specific receptor that’s common in melanoma, perhaps with a monoclonal antibody :

    http://cancerres.aacrjournals.org/content/64/15/5385.full.pdf

    Or some other biological agent. Best to ask Karmonos. As the trial has been going on for a little while, they may share a bit of what they’re seeing. They were very helpful with us.

    I’m sorry you have to go through this.

    Jeff

    #59696
    Catherine Poole
    Keymaster

    Jim,

    I would look into some clinical trials in Canada, try the top places, such as those listed in our global sources. Also, the PD1 trial is in a number of places and that is the promising immunotherapy. Some folks also try a reinduction of Zelboraf after a break. The BRAF/Mek combo would be another choice for you and should be approved shortly in the U.S. I would keep looking beyond what you’ve been offered.

    #59697
    jnfife
    Participant

    Thanks to all for your valued input and suggestions.

    I’m very grateful.

    Jim N.

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