Home Forums Melanoma Diagnosis: Stage IV Anti PD-1 question

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    Is this an immunotherapy? Similar to Ippi? If you failed on Ippi and IL2 is there reason to think Anti-PD 1 will fail too? My husband has been on Zelboraf for 21 months and I think its starting to fail and I want to be informed as to what our next move could be.


    Catherine Poole

    PD1 stands for programmed death (of melanoma cells) and is an immunotherapy with a reported higher response rate than Yervoy. The prior therapies may become an issue when they number more than 3 I believe for the BMS PD1. I will double check on that. I don’t think we know if prior failure to Yervoy means failure on PD1 and certainly wouldn’t correlate to the small response rate of IL2 of 6%. Sometimes it is a good idea to go off Zelboraf and then back on. I hope this answers your questions.

    Catherine Poole

    For the Merck PD1 trials there is no restriction on prior number of therapies you can have.

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