Home Forums Melanoma Diagnosis: Stage IV Any news on Anti PD1 Approval

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  • #21971
    Angela21
    Participant

    We wanted to get my husband Tim into EAP, but he had brain mets. He had gamma knife surgery on them and chose to go on temodar while waiting for Anti PD1 approval. Does anyone have any information about when FDA approval will happen? He was diagnosed in Nov.,2011 and has had interferon, radiation, yervoy and carbo-taxol.

    Thanks,

    Angela

    #64382
    Catherine Poole
    Keymaster

    I am assuming he is braf negative? Sorry, no word yet, but probably the fall. If his brain mets are stable, then he can join the EAP. He should try to get signed up anyway. What location are you trying?

    #64383
    Angela21
    Participant

    Yes, he is Braf negative. We went to University of Pittsburgh and met with them to get him into EAP in early April. I understand they are not opening EAP there yet. Then he had the MRI done that showed the brain mets. He had the gamma knife on May 2nd. How long would he have to wait to try for a stable MRI? He is being treated at Ohio State James cancer center.

    Thanks,

    Angela

    #64384
    Catherine Poole
    Keymaster

    Pittsburgh is not opening an EAP for PD1 I was told. I can help you find other locations. I believe Philadelphia area centers are opening now, one in NJ. Showing about 5 in Ohio, not sure how close they are to accrual. Cleveland Clinic is one you might try. I can email you the list if you email me: cpoole@melanomainternational.org for Ohio if you’d like.

    #64385
    Angela21
    Participant

    Thank you, Catherine,

    I sent an inquiry to the MAYO clinic website with his information. At least we know it is up and running there already. Hopefully I will hear from them soon. Thank you so much for your support.

    Angela

    #64386
    Catherine Poole
    Keymaster

    You may want to call them. There are a lot of folks trying to get in to the trial. Good luck!

    #64387
    Alicia
    Participant

    There is a PD1 trial recruiting patients with brain mets.

    http://www.clinicaltrials.gov/ct2/show/NCT02085070

    #64388
    dhrahn
    Participant

    My husband had stereotactic radiosurgery for brain lesion and started eap pd1 within 2 weeks. I don’t believe there is a “waiting” period as long as they are off steroids. We are being treated at The Angeles Clinic in Los Angeles with Dr. Hamid.

    #64389

    Is it true that I need to have failed yervoy in order to get in the PD1 trial? I am confused. I have been on Zelboraf for a year and have now switched to Tafinlar because of sun sensitivity. I have remained stable but require blood transfusions frequently. Would like to see shrinkage as this stops the blood loss.

    #64390
    Catherine Poole
    Keymaster

    To get into the expanded access Merck PD1 you must have failed IPI first and the braf drugs.

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