Home Forums Melanoma Diagnosis: Stage IV BMS ipi-nivo combo trial — 13 week scan update

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  • #21674
    Sula
    Participant

    hi —

    I have stage IV melanoma with several abdominal mets, and am travelling to Memorial-Sloan-Kettering in NY to be part of this trial:

    CA209-004, A Phase Ib, Open-Label, Multicenter Dose-Escalation Study of MDX-1106 (Nivolumab; BMS-936558) in Combination with Ipilimumab (BMS-734016) in Subjects with Unresectable Stage III or Stage IV Malignant Melanoma

    I’ve received my first four doses (the ipi & nivo in combination), and am now going to get the nivolumab alone every two weeks.

    I recently had my first scans, and there were no new mets, and an overall reduction in the existing lesions of 62%. (the largest was about 7 x 5 cm, and that’s shrunk by half).

    The next scans will be in a few weeks. I’m on Prednisone now for some Ipi-induced colitis, but it’s ok.

    Cautiously relieved and hopeful that others can also benefit from the explosion of research happening right now….

    -Ursula

    http://ursulasmelanomablog.wordpress.com” class=”bbcode_url”>http://ursulasmelanomablog.wordpress.com

    #63001
    Anonymous
    Guest

    Bless you Ursula. That’s wonderful news.

    You know mathematically, a 50% reduction in tumor dimensions (length, width and thickness) is an ~ 4-8X reduction in volume. :)

    Jeff

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