BRAF/MEK combo approved in the US! Home › Forums › Melanoma Diagnosis: Stage IV › BRAF/MEK combo approved in the US! This topic is empty. Viewing 6 posts - 1 through 6 (of 6 total) Author Posts January 9, 2014 at 8:15 am #21736 bettinParticipant Good news for BRAF pos Melanoma patients- the FDA has just approved the GSK BRAF-MEK combo which prolongates time to resistance and that with fewer side effects! http://www.gsk.com/media/press-releases/2014/gsk-gains-accelerated-fda-approval-for-combination-use-of-mekini.html Now fingers crossed that the EMA follows closely, so that also European patients can get access to what has been promising ASCO news for the last 3 times. Wishing you all the best, Bettina January 9, 2014 at 1:01 pm #63318 MathewRParticipant Thanks for posting. Given where I started (heavy tumor burden), I literally owe my life to this combination and am forever grateful to the scientists, clinicians and patients who helped make it available. January 9, 2014 at 1:26 pm #63319 Catherine PooleKeymaster This is good news! Although I did hear that Germany is not approving because of the cost for either of the agents. January 9, 2014 at 5:18 pm #63320 Mike6413Participant This combo worked for me for 6 months. I acheived a 66% tumor reduction, but then went resistant to it. I did have to undergo a reduction in dosage due to side effects, mainly kidney failure. but the drugs did work, and fast. January 9, 2014 at 6:01 pm #63321 bettinParticipant Good to hear that the drugs worked for you!! In Europe, the combo isn’t approved yet but yes, cost will be an issue here. It is so depressing- what is the point of developing drugs that people cannot afford?!! January 9, 2014 at 7:37 pm #63322 MathewRParticipant Mike, if you’re able to say, what treatment did you move to after the combo stopped working? Author Posts Viewing 6 posts - 1 through 6 (of 6 total) The forum ‘Melanoma Diagnosis: Stage IV’ is closed to new topics and replies.