Home Forums Melanoma Diagnosis: Stage IV Conference Tomorrow: Society for Melanoma Research

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  • #21675
    Catherine Poole
    Keymaster

    This is the Society for Melanoma Research, an international group. The meeting will possibly disclose further data by Merck and others on PD1. I will be there to bring back anything I feel is of value to you. Here’s the link: http://www.melanomacongress.com/

    #63002
    erinmay22
    Participant

    Excited to hear what they may be presenting! Just had dose #15 on Thursday! Next set of scans will be Dec 27th! eek!

    Hope all is well!

    Thanks for the updates!

    Erin

    #63003
    Shirley Z
    Participant

    Hi Erin,

    How have you been? I have really fallen behind on things. Hope you are doing well. Think of you often.

    Shirley Z

    #63004
    Catherine Poole
    Keymaster

    Two things of interest I thought: Chapman from MSK showed that in a small sample it was best to leave the BRAF agent before progression and move to another agent rather than wait. Also, Caroline Robert from Paris (one of Pati’s doctors) mentioned data on the Merck PD1 raised its response from 38% to 41%. Also had some higher numbers of long term survival. Here are some details: http://online.wsj.com/article/PR-CO-20131118-907722.html?dsk=y

    I read a lot of posters and listened to a lot of speakers, It didn’t appear that PDL was as promising as initially thought from Sossman. more…later

    #63005
    erinmay22
    Participant

    Shirley – I’ve been doing well! Hope you are doing well also!! Scans end of Sept continue to show shrinkage! So all good news. Started the Merck PD1 trial Jan of this year.

    Catherine – thanks for the info!

    Erin

    #63006
    Catherine Poole
    Keymaster

    Also, it was mentioned this Phase III trial will be pivotal with Merck Pd1 up against IPI, http://clinicaltrials.gov/show/NCT01866319

    I can’t see why an earlier approval isn’t in the works!

    And there was a bit of discussion about radiation and IPI together

    #63007
    MathewR
    Participant

    Catherine, thank you for the information. Did you catch the report late in the day on the GSK combo? It was on the conference agenda for sometime around 5pm.

    #63008
    Maureen038
    Participant

    Catherine,

    Thanks for all the information! I am very interested in the ipi/ radiation combo if my husband’s trial doesn’t give him good results. He has lung mets. Was it talked about favorably? Thanks!

    Maureen

    #63009
    Catherine Poole
    Keymaster

    Maureen,

    It definitely was spoken of in positive terms, they spoke of using stereotactic radiation on liver and lung mets and then adding PD1 or IPI. Nothing concrete to report, I’m searching for studies to cite more. But I do believe there won’t be just one agent in this therapy for melanoma but a progression and combination for best results.

    Did not hear any late breaking news on the braf/mek combo but will look for this. I do think it is important that trials are showing that patients should not stay on these drugs until progression of disease. Makes sense to move to Pd1 once the disease burden is low for better long term regression.

    #63010
    Violeta
    Participant

    All of these are very interesting news for me, for us! Previously most of the doctors advised Braf inhibitor until progression. Looking back I am sorry I was not aware about a lot of things. Thanks Catherine. I am also interested in the latest news on GSK Braf/MEk combo..I will keep reading and checking the link you posted it.:-)

    #63011
    MathewR
    Participant

    Catherine,

    Chapman’s statement regarding BRAF treatment is interesting. Perhaps you could impress upon him and others that the “wording” of trials will need to be revised so as to not require prior treatment failure or disease progression–or at least to exclude BRAF inhibitor-treated patients from such requirements. (In addition, the folks who run the trials would need to be educated on this point.) This would permit one to voluntarily stop taking a BRAF inhibitor in order to move to a trial. Thanks again.

    #63012
    Catherine Poole
    Keymaster

    Absolutely! The wording of trials is so important and not easy to understand. My understanding of the PD1 trial is that it requires prior BRAF therapy for BRAF positive, but not progression. I will ask my contact to clear that up.

    #63013
    MathewR
    Participant

    Merck’s Phase III trial does not have the wording regarding treatment failure/disease progression. However, when I contacted a site, and they in turn contacted Merck, the consensus seemed to be that they wouldn’t support voluntarily stoppage. I didn’t press the point because I personally needed additional reduction in my tumor burden before considering a move.

    #63014
    Maureen038
    Participant

    Thanks Catherine for the important information. I appreciate it very much! I’m so hoping that my husband won’t need this treatment and the study he’s on now will work. He will have scans in the beginning of January.

    Maureen

    #63015
    Catherine Poole
    Keymaster

    I am still waiting to hear back on the Merck trial re: stoppage of braf drugs, reached out to many! Also if there were any interesting disclosures at the SMR meeting I missed. I’ll let you know.

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