Home Forums Melanoma Diagnosis: Stage IV CraigG Status Update

  • This topic is empty.
Viewing 5 posts - 1 through 5 (of 5 total)
  • Author
  • #21498

    Just another update from me CraigG


    1991 : First melanoma removed

    2005 : Melanoma reappears

    (No particular order)

    3 craniotomies later

    2 clinical studies

    Several surgeries, radiation, etc


    15th week of EMR2000066-006, 3rd clinical study

    Last set of scans show no new growths, nothing getting bigger

    First side effect was rash/acne on face and funny pain on scalp. I called scalp pain ‘hair on fire’

    since it never lasted very long, 3-4 seconds. All under control by week 5 or so.

    Very sun intolerant – Took a few weeks before it happened – Sunburned arms just going out to water plants and pick up mail…top of hands are now kinda sore…got ointments for all this

    All side effects covered pretty well by my oncology staff

    Never take a bunch a pills without some food – oops forgot – got the worst case of dry heaves

    No major complaints – well I wish I had a bit more energy to do things..



    Week 21 – Good news

    Most recent scans show 3 tumors inactive or gone. 2 no growth and lower activity.

    My unrelated problem with my heart, Atrial Fibrillation, A-Fibs, was what was really making me think that my fatigue and shortness of breath were all related to my study drug. 6 days in hospital took care of all that. They modified my heart medications.

    So now I am almost feeling normal.

    Catherine Poole


    That all sounds good and thanks for the tips. Now, can you tell me what trial this is? I’ve not heard of this therapy and couldn’t find anything on google.



    Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors

    Basic Trial Information

    Trial Description


    Eligibility Criteria

    Trial Contact Information

    Basic Trial Information

    Phase Type Status Age Sponsor Protocol IDs

    Phase I Biomarker/Laboratory analysis, Treatment Active 18 and over Pharmaceutical / Industry EMR 200066-006


    Trial Description


    This research trial is testing a combination of two experimental drugs, MSC1936369B (Mitogen-activated protein extracellular signal-regulated kinase (Mek) Inhibitor) and SAR245409 (Phosphatidylinositol 3-kinase (Pi3K)/Mammalian Target of Rapamycin (mTOR) inhibitor), in the treatment of locally advanced or metastatic solid tumours. The primary purpose of the study is to determine the maximum tolerated dose of the drug combination.

    I’m taking it through Pinnacle Oncology, Scottsdale AZ.


Viewing 5 posts - 1 through 5 (of 5 total)
  • The forum ‘Melanoma Diagnosis: Stage IV’ is closed to new topics and replies.