Home Forums Melanoma Diagnosis: Stage IV CraigG Status Update

  • This topic is empty.
Viewing 5 posts - 1 through 5 (of 5 total)
  • Author
    Posts
  • #21498
    CraigG
    Participant

    Just another update from me CraigG

    Background:

    1991 : First melanoma removed

    2005 : Melanoma reappears

    (No particular order)

    3 craniotomies later

    2 clinical studies

    Several surgeries, radiation, etc

    Current:

    15th week of EMR2000066-006, 3rd clinical study

    Last set of scans show no new growths, nothing getting bigger

    First side effect was rash/acne on face and funny pain on scalp. I called scalp pain ‘hair on fire’

    since it never lasted very long, 3-4 seconds. All under control by week 5 or so.

    Very sun intolerant – Took a few weeks before it happened – Sunburned arms just going out to water plants and pick up mail…top of hands are now kinda sore…got ointments for all this

    All side effects covered pretty well by my oncology staff

    Never take a bunch a pills without some food – oops forgot – got the worst case of dry heaves

    No major complaints – well I wish I had a bit more energy to do things..

    CraigG

    #62066
    Craig_G
    Participant

    Week 21 – Good news

    Most recent scans show 3 tumors inactive or gone. 2 no growth and lower activity.

    My unrelated problem with my heart, Atrial Fibrillation, A-Fibs, was what was really making me think that my fatigue and shortness of breath were all related to my study drug. 6 days in hospital took care of all that. They modified my heart medications.

    So now I am almost feeling normal.

    #62067
    Catherine Poole
    Keymaster

    Craig,

    That all sounds good and thanks for the tips. Now, can you tell me what trial this is? I’ve not heard of this therapy and couldn’t find anything on google.

    #62068
    Craig_G
    Participant

    EMR200066-006

    Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors

    Basic Trial Information

    Trial Description

    Summary

    Eligibility Criteria

    Trial Contact Information

    Basic Trial Information

    Phase Type Status Age Sponsor Protocol IDs

    Phase I Biomarker/Laboratory analysis, Treatment Active 18 and over Pharmaceutical / Industry EMR 200066-006

    NCT01390818

    Trial Description

    Summary

    This research trial is testing a combination of two experimental drugs, MSC1936369B (Mitogen-activated protein extracellular signal-regulated kinase (Mek) Inhibitor) and SAR245409 (Phosphatidylinositol 3-kinase (Pi3K)/Mammalian Target of Rapamycin (mTOR) inhibitor), in the treatment of locally advanced or metastatic solid tumours. The primary purpose of the study is to determine the maximum tolerated dose of the drug combination.

    I’m taking it through Pinnacle Oncology, Scottsdale AZ.

    Craig_G

    #62069
    Craig_G
    Participant
Viewing 5 posts - 1 through 5 (of 5 total)
  • The forum ‘Melanoma Diagnosis: Stage IV’ is closed to new topics and replies.