decision time

[mazz75]

Hello catherine

I would like to know if the Trametinib and Dafrabenib have been approved in Europe as single agents?

My sister was ned on Zelboraf for almost a year and 7 weeks ago 2 brain mets were discovered which were sucessfully removed 2 weeks ago. Her oncologist is very happy with her fast recovery and he ordered a new set of scans for next week.

He is of the opinion that Zelboraf is still working and she should continue with Zelboraf.

From what I read Trametinib and Dafrabenib work better than Zelboraf on the brain.

Catherine what is your opinion?

[Catherine Poole]

You do get an added bonus with the MEK addition and if she is responding to Zelboraf she should also respond to the BRaf/Mek combination. I know it is approved in the UK, not sure of Europe’s status. There is a study that shows this combo does have some positive response for brain mets but in a small study. There are many PD1 trials in Europe, have you checked them out?

[mazz75]

Hello Catherine

We asked about the Anti Pd1 trial and he said that sinse she has been already 7 weeks off treatment and she has to wait an other 8 to 12 weeks from the operation, it would not be a good idea to stay so long with out any form of treatment. However they will take the final decision when the scan results are ready.

Regarding the Braf – Mek combo its fine they are approved in UK since she is being treated at The Royal Marsden. Can these be prescribed together in UK?

regards

Maggie

[Catherine Poole]

I don’t quite understand the waiting period if her mets are stable. As far as I know both drugs, braf/mek are approved in UK.

[mazz75]

Her oncologist said she has to wait from 8 to 12 weeks from the operation, I cannot understand it either. Is that normal? Next week she has full body scans and they will decide from there. I am constantly praying for her , its so frustrating.

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