Hi Cheris,
I responded to the BRaf combo SO quickly. Within 72 hours, I had no symptoms of melanoma (prior I had suffered from pain in legs and hips, significant fever). The response was so rapid that I called my Oncologist to find out whether there are narcotics in the medicine (there are not).
Unfortunately for me, I did not understand the degree of “sun sensitivity” that I would suffer. I walked from my car to the house and suffered severe burns. 2 minutes on my porch giving leaf raking directions (in October) and my legs blistered and the subsequent burn symptoms led to mouth ulcers and fevers.
If you are prescribed Zelboraf, don’t leave a speck of skin unprotected, including your lips.
Taflinar is said to not be so dramatic, but the fever associated with that drug can be debilitating for some.
Would you mind sharing your oncologist’s strategy? Were you partially/completely/not successful on Ipi?
Leslie
PS: Catherine will know better, but I have always assumed that Taflinar and Zelboraf (both with similar actions) combined with Mekinist are interchangeable as the “BRaf Combo.”