Home Forums Melanoma Diagnosis: Stage IV Different Braf/MEK combos

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  • #22324
    cheris
    Participant

    I am getting very confused on the various forms of Braf/Mek combos. Is one better than the other? How does the oncologist choose the best combo for the patient? This will be my next step. Thanks wonderful people.

    Cheris

    #66171
    Catherine Poole
    Keymaster

    The only one approved by the FDA and having significant data is the GSK dabrafenib and mekinist. Zelboraf now has a combo MEK but it is still in trial. So until we get robust data on that one, I would go with the dabra/mek. Are there others I’ve missed?

    #66172
    Lesli
    Participant

    Hi Cheris,

    My doctor prescribed Zelboraf with the Mekinist. When I asked why he had opted for Zelboraf, his reply was that he “knew” Zelboraf better, preferred extreme sensitivity to sun over the fever that can come from Taflinar.

    I lasted 9 months to the day on the Z/M combo.

    Leslie

    #66173
    cheris
    Participant

    Thank you Catherine and Lesli. I think I may be confusing brand names and scientific names.

    Lesli, did you have any side effects?

    Cheris

    #66174
    Lesli
    Participant

    Hi Cheris,

    I responded to the BRaf combo SO quickly. Within 72 hours, I had no symptoms of melanoma (prior I had suffered from pain in legs and hips, significant fever). The response was so rapid that I called my Oncologist to find out whether there are narcotics in the medicine (there are not).

    Unfortunately for me, I did not understand the degree of “sun sensitivity” that I would suffer. I walked from my car to the house and suffered severe burns. 2 minutes on my porch giving leaf raking directions (in October) and my legs blistered and the subsequent burn symptoms led to mouth ulcers and fevers.

    If you are prescribed Zelboraf, don’t leave a speck of skin unprotected, including your lips.

    Taflinar is said to not be so dramatic, but the fever associated with that drug can be debilitating for some.

    Would you mind sharing your oncologist’s strategy? Were you partially/completely/not successful on Ipi?

    Leslie

    PS: Catherine will know better, but I have always assumed that Taflinar and Zelboraf (both with similar actions) combined with Mekinist are interchangeable as the “BRaf Combo.”

    #66175
    rick1981
    Participant

    Hi Cheris,

    My wife also had an extremely quick response to the BRAF/MEK combo, some sub-skin lesions literally “disappeared like snow under the sun”.

    In terms of names (first is the brand name, second the medical name):

    Tafinlar = Dabrafenib

    Mekinist = Trametibib

    Zelboraf = Vemurafenib

    Hope that helps,

    Rick

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