Home Forums Melanoma Diagnosis: Stage IV ‘Drug holiday’ trial opening in Netherlands and Denmark

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  • #21897
    Hein
    Participant

    Hi everybody,

    Today NKI/AvL in the Netherlands announced they are starting a big trial on resistance

    to Vemurafenib disappearing after a medication pause. The full newsfeed you can find here: http://www.nki.nl/topmenu/about-the-nki/news/drug-holiday-effect-in-patients-with-melanoma-resolved/.

    Also in Denmark this trial will open, both of them probably by May/June.

    Great news but old news for us forummembers as Pati and Quentin allready reported about this back in 2012.

    Hein

    #63950
    Violeta
    Participant

    Exactly now I sow the article about reversible resistance , thanks a lot for sharing!

    #63951
    Catherine Poole
    Keymaster

    Thanks for posting this. We are celebrating Pati’s life with this MICAB conference in Brussels. It will be all about clinical trials and their design etc. Her work will live on as will Quentin’s legacy.

    #63952
    Hein
    Participant

    Pati is still watching over us and doing the thing she did so well…

    This news just a day before her memorial service?

    Hein

    #63953
    Catherine Poole
    Keymaster

    At the MICAB conference one of the professors explained this “holiday’ effect has only been proven in animal models. We are far from knowing dosage, and whether this may serve patients well in the long run. Time will tell.

    #63954
    Violeta
    Participant

    Catherine, I think the professor form m-icab conference was speaking about the study on mouses that has been published (edit) in Febr. 2013 http://www.nature.com/nature/journal/v494/n7436/full/nature11814.html or https://www.ucsf.edu/news/2013/01/13389/drug-resistant-melanoma-tumors-shrink-when-therapy-interrupted

    But the article from Nature which I mentioned (and which Hein post it as news feed) was published last Thursday on 26 March 2014: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13121.html

    Is good to read the entire article in order to draw a conclusion, but what I understood from the abstract is that experiments were done on human tumors. I hope I am not wrong. edit:Who knows… maybe clinical trials will follow.

    #63955
    Hein
    Participant

    Violetta is correct. I checked it today with NKI/AvL. Ever since I reported them some two years ago about Pati’s thread on this forum about starting on Vemu again, NKI tried it with a few patients. So the publication in Nature last week is based on results on patients.

    I actually asked Dr. Schadendorf after his presentation at M-ICAB if he was aware about the latest Nature-article, but he was surprised and had not yet seen it.

    Hein

    #63956
    Catherine Poole
    Keymaster

    Oh I want to believe, but want to be certain we do know proper dosages when this is tried. There are also new BRAF agents in trial soon to join the others. So it will be interesting.

    #63957
    Violeta
    Participant

    Thank you Hein for confirmation! I had also this impression, that prof. did not know yet. For me – and I am sure not only – this research means a lot. It is opening more perspectives within the treatment with Braf mutation inhibitors..

    I hope too to see soon clinical trials on this subject!

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