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March 27, 2014 at 8:46 pm #21897
Today NKI/AvL in the Netherlands announced they are starting a big trial on resistance
to Vemurafenib disappearing after a medication pause. The full newsfeed you can find here:
Also in Denmark this trial will open, both of them probably by May/June.
Great news but old news for us forummembers as Pati and Quentin allready reported about this back in 2012.
HeinMarch 27, 2014 at 10:20 pm #63950
Exactly now I sow the article about reversible resistance , thanks a lot for sharing!March 28, 2014 at 6:55 am #63951 Thanks for posting this. We are celebrating Pati’s life with this MICAB conference in Brussels. It will be all about clinical trials and their design etc. Her work will live on as will Quentin’s legacy.March 28, 2014 at 7:46 am #63952 Pati is still watching over us and doing the thing she did so well…
This news just a day before her memorial service?
HeinMarch 30, 2014 at 7:00 pm #63953
At the MICAB conference one of the professors explained this “holiday’ effect has only been proven in animal models. We are far from knowing dosage, and whether this may serve patients well in the long run. Time will tell.March 30, 2014 at 9:32 pm #63954 Catherine, I think the professor form m-icab conference was speaking about the study on mouses that has been published (edit) in Febr. 2013 or http://www.nature.com/nature/journal/v494/n7436/full/nature11814.html https://www.ucsf.edu/news/2013/01/13389/drug-resistant-melanoma-tumors-shrink-when-therapy-interrupted
But the article from Nature which I mentioned (and which Hein post it as news feed) was published last Thursday on 26 March 2014:
Is good to read the entire article in order to draw a conclusion, but what I understood from the abstract is that experiments were done on human tumors. I hope I am not wrong. edit:Who knows… maybe clinical trials will follow.March 31, 2014 at 8:27 pm #63955
Violetta is correct. I checked it today with NKI/AvL. Ever since I reported them some two years ago about Pati’s thread on this forum about starting on Vemu again, NKI tried it with a few patients. So the publication in Nature last week is based on results on patients.
I actually asked Dr. Schadendorf after his presentation at M-ICAB if he was aware about the latest Nature-article, but he was surprised and had not yet seen it.
HeinMarch 31, 2014 at 11:18 pm #63956
Oh I want to believe, but want to be certain we do know proper dosages when this is tried. There are also new BRAF agents in trial soon to join the others. So it will be interesting.April 2, 2014 at 12:58 pm #63957 Thank you Hein for confirmation! I had also this impression, that prof. did not know yet. For me – and I am sure not only – this research means a lot. It is opening more perspectives within the treatment with Braf mutation inhibitors..
I hope too to see soon clinical trials on this subject!
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