Home Forums Melanoma: Stage III explain in plain english new diagnosis?

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  • #21243
    320666a
    Participant

    Two years ago I was diagonosed with stage 3 melanoma of the right forearm, had surgery, was successful. Recently had a small under the skin bump show up, had an incision to remove, and the pathology report stated:

    metastic malignant melona with extracapsular extension, present on the margin…noting, microscopic examination revealing nodualar desposits of lymph nodes with a surrounding rim of lymphocytes in aresas. There is extension into the surrounding fat,. The melanocytes stain with antibodies against melan-A, S100, and HMB45. All control stains stain appropriately.

    I have scheduled a Pet-scan, to check status in a few days. thoughts, anything I should be additionaly aware from previous/history, events from others?

    Thanks

    #60423
    Catherine Poole
    Keymaster

    Your doctor should discuss with you, but this sounds like an intransit met or some type of metastasis from the original lesion. How close to the original tumor was it? Sometimes this happens and you will not see any further issues after removal. It might signal the time to do some systemic therapy such as immunotherapy. I hope this helps you understand this.

    #60424
    Shirley Z
    Participant

    Hi,

    I was curious also as to where the lump occured in regards to your previous melanoma.

    I am stage IIIC. My original melanoma was on my left big toe. One day before my 3 yr mark of NED I felt a lump in my shin. It was a direct line up from the original on my toe. It was two lymphnodes with melanoma. It had attached itself to a vein. I had surgery to remove it and will be 4 yrs out from that surgery in late August. What Catherine states about possibly not having any further issues could be a possibility. I am hoping that is the case for me.

    For now, although you can never say never with melanoma I seem to be beating the odds from a very poor prognosis. It can and does happen. You have to constantly stay on guard.

    The only treatment I have had is surgery. For me it was the right thing. For some its not. You are the only one that can decide what is right for you.

    Wishing you the best.

    Shirley Z

    #60425
    320666a
    Participant

    Oruginal melanoma was in right forearm, the bump that appeared and has been dissected appeared on the left side of my waise (love handle). I waiting for results of recently taken Pet-Scan.

    #60426
    Shirley Z
    Participant

    Wow thats strange that your original was on the right

    side and the recur occured on your left. It just goes to show

    how unpredictable melanoma can be.

    Good luck with the pet scan results. Keep us posted.

    Shirley Z

    #60427
    320666a
    Participant

    Good News, Pet Scan was Negative…..However, due to fact that when biopsy was taken on the surrunding area (few weeks agao) there was some signs of melanoma. I’m being scheduled for another incision to ‘clean up the surrounding area’ to make sure all of it was taken out..

    The biopsy that was taken from the small lump that occured on my left hip (beneath the love handle area) tested positive for melanoma. Because this is rare—showing up my mine left hip side—when original melanoma detected was found within my right forearm (2 years ago). I will be scheduing an appointment with a specialist to discuss.

    Note: When surgery was first performed to take out melanoma from my right forearm area (2 years ago) I choose to take the ‘wait and see’ approach following this since nearest lymph node had insignificant test for additional traveling of it to that site. The fact that now melanoma has been found on my left side (love handle/above hip area) seems rare, thus appointment to discuss with specialist to review and state possible avenues?

    Someone had told me, that fact that now melanoma has been detedted again (2 years after first surgery to remove) the cycle of the 5 years starts up once again to determine if cure has been accomplished–does anyone know if this is true?

    …..anyone having anything like this, let me know. I’ll keep you informed. I’m feeling fine.

    #60428
    Shirley Z
    Participant

    Happy to hear your pet scan was negative. Glad you have appointment to discuss things further. That is really strange that this melanoma is a metastasis from the original and on the opposite side. Although, It does happen sometimes.

    Good luck with the reincision. Maybe there is a trial available for you, although you will probably be back to NED status if they are able to fully remove the met on the hip.

    Keep us posted. Glad to hear you are feeling well.

    Shirley Z

    Forgot to mention that i was also told because of my recur the 5 year thing started over also. Although the further out you get the better, I really don’t think you can ever consider yourself safe. People have gone yrs ( for example Jonathan) and have had recurs. Others continue to do well. We always have to stay alert.

    Good Luck!

    Shirley Z

    #60429
    320666a
    Participant

    I was diagnosed two years ago with stage III melanoma on my right forearm…. had a good incision and all was taken out. Presently, in wait and see time period -of which I choose.

    Recently a small lump occured beneath skin in area just above left hip, below love handle?

    Had it take out, was positive for Melanoma…. and having additional incision for the margins.

    Question is: Has Anyone had a transient node like this happent to them, or have had occurance go from one side of your body (right forearm) to above left hip area-as in my case?

    I will be seeing specialist after scheduled incision for margins.

    Note: When first diagones two years ago, I did not opt for removal of lymph nodes above right forearm area because significance of additional signs of melanoma were not there-Thus opted to wait and see period.

    Thanks in advance.

    #60430
    320666a
    Participant

    I was a previously level 3-A (after first diagnosed in November 2010), have taken path of ‘wait and see’ due to being level 3, with regular scans, and seeing dermatologists, with regular scans and check ups…..about year and a half ago have small melanoma appear above left hip (opposite side of original site which was right forearm………have successfully removed………..however due to this second occurance….. specialist — now has me at level lV…………Recently (appx. year later) … I had a scan and spot showed up from my right buttock…..took a biopsy…… Result unfortunately came back–Metastatic malignant melanoma. with following comment:

    The neoplastic cell are HMB45 positive and S-100 negative by immunohistochemical stain. The immunohistochemical profile supports malignant melanoma.

    I have an appointment with specialist late next week, any thoughts, or insights on report received?

    Thanks

    #60431
    Catherine Poole
    Keymaster

    Surgery should handle it. You may not deal with it again. Otherwise you can look at some therapies that are systemic.

    #60432
    abdorma
    Participant

    I am going to offer an opposing point of view from Catherine which I don’t like to do but am basing it on my husband’s melanoma experience. He was diagnosed IIIB in March 2011 after a WLE and sentinel node biopsy that showed only intransit mets with no lymph node involvement. In Dec of 2011, he had two mets one in lung (opposite side of original melanoma) and one in a lymph gland in branchial tree both of which he had surgically removed; in May 2012, he had one lymph node under armpit (again opposite side of body from original site) surgically removed and in August 2012 was found to have multiple tumors in lungs, on spine and in soft tissue. He was treated successfully for 6 months with Zelboraf and when his disease progressed in February 2013, had four rounds of IPI which was not effective in stopping progression. He died in Sept 2013.

    If I had to do our life over again, I would have started IPI after the May 2012 lymph node was discovered. That lymph node had extranodal encapsulation which I believe yours did as well. His oncologist called that “letting the horse out of the barn” and said that his chances of recurrence went way up. So I am not as big a fan as “cut it out” and “watch and wait” as I once was and certainly there is now more knowledge and experience with IPI, Zelboraf and the anti PD1 trials.

    My theory is: start IPI or get in a PD1 trial BEFORE you have any more tumors. Give your body a chance to find and kill those little melanoma buggers before they have a chance to get more of a foothold in your body. Certainly there are side effects but if you have success with the treatment, well worth the pain and discomfort (easy for me to say —- I didn’t have them!)

    Before your appointment with the specialist which I am assuming is an oncologist, I would listen/watch the webinars on this site about various immune therapies so you understand what these treatments do. We found them very useful and felt more prepared to ask questions and have an idea of what we thought might be the next step.

    I hesitated to write this reply as not every Stage III case ends as my husband’s did. There are many people who are Stage III that watch and wait and have good results with that approach. Shirley is one of them. I most sincerely hope you never have another melanoma. But having watched firsthand how fast melanoma can get in the lymph system and spread its dirty little self around, I now believe proactively and systemically fighting any melanoma cells lurking around the lymph system waiting to find a good spot to land might be a better approach.

    Whatever you choose to do, I most sincerely wish you a good outcome.

    ann

    #60433
    Catherine Poole
    Keymaster

    Actually Ann and I agree. After surgery, systemic therapy is a great idea. However, you will be limited to IPI. You can’t get into PD1 until you fail IPI in the expanded access program. You might be able to find a PD1 trial, but they are scarce right now as these drugs move to approval. Did you have BRAF testing? That should happen too for further choices.

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