Yesterday we went to see Dr. Daud for the scan results after 12 weeks Anti-PD1. She appeared to be completely stationary. So, no growth is good news, but shrinkage would have been better. To remind you, Mariëtte’s melanoma was extremely indolent to start with, so I find it hard to make a definitive conclusion that the Anti-PD1 is working.
I was actually prepared for a negative result after finding this paper:
Apart from being a rare case of indolence, she is also acral lentiginous, and from that paper I thought I could conclude that it is very unlikely that that combines with the ligand PD-L1 expression. Dr. Daud didn’t want to jump to that conclusion.
Another thing I thought about regarding her indolence is that she has alpha 1-antitrypsin deficiency. When you look up how that works, it could sound like a build-in immune therapy.
Anyway, the short story is: ongoing Anti-PD1 infusions and another 3 month of waiting.