Home Forums Melanoma Diagnosis: Stage IV Four year survival rates for Ipi

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  • #21370
    Steven
    Participant

    According to this study (http://www.ncbi.nlm.nih.gov/pubmed/23666915) 10mg has higher survival rates than 3mg. Does anyone know if studies are ongoing regarding best dosage?

    Does the FDA ever change a dosage once approved?

    #61340
    Catherine Poole
    Keymaster

    Thanks Steven, that is interesting. I’ve asked BMS to respond.. then also our scientific board. It was approved at the lower 3mg dosage but docs could up it.

    #61341
    Steven
    Participant

    Thanks Catherine.

    I’m guessing there are a few treatment naive folks who would want to take 10MG and hope for the 38-50% results. This paper reports at 4 years because that is where they were at, but those numbers could hold up for many more years.

    #61342
    Catherine Poole
    Keymaster

    This was not the definitive study, that you need the phase III trial for I’m told. Still more promising is the PD1 and the IPI combined. Will be posting that phase III trial locations soon.

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