I learned a lot today at the webinar, especially from asking your excellent questions! As you are pointing out, those who fail IPI won’t necessarily fail PD1 and vice versa, that was interesting to me! Also that as little as a rash from IPI can be a sign of response. Jedd is a great doctor and certainly excellent at explaining these complicated therapies. I’m definitely in his camp that combinations will be the future, and maybe not all at once, but in succession. He said that the IPI/Zelboraf combo proved too much with side effects so they stopped the trial. So careful mixing will yield interesting results in the future.
The webinar is now up on the website for those of you who missed it.