Home Forums Melanoma: Newly Diagnosed – Stages I & II Interesting article about Redheads and Melanoma

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  • #20734
    PhillyRed
    Participant

    Today I read this interesting article about the increased risk of melanoma in redheads:

    http://www.medpagetoday.com/HematologyOncology/SkinCancer/35664

    #57309
    Catherine Poole
    Keymaster

    We posted this on facebook and I wrote that this is more a matter of phenotype than genes. It is true that redheads have the fairest of skin, but some blondes do and even folks like me with brown hair do. So the gene aspect maybe slightly incorrect.

    #57310
    PhillyRed
    Participant

    Actually what the article is saying is that redheads may be at an even greater increased risk of developing melanoma than non-redheads due to the combined effect of phenotype and genotype, over just the risk of phenotype (fair skin). The genotype of a redhead which leads to the fair/skin, freckling, and red hair, is the result of having 2 copies of the recessive mutant melanocortin receptor gene that results in the predominant expression of pheomelanin (red-yellow melanin pigment) over the dominant, more prevalent, gene that codes for eumelanin (brown-black melanin pigment) which is the predominant form of melanin in skin, hair, and eyes worldwide. What the study indicated was that pheomelanin provides poor protection to the skin from UV radiation, but that in addition, pheomelanin has a greater capacity to generate reactive oxygen radicals that may be carcinogenic than does eumelanin. For example, in the study described, red mice had a much higher incidence of melanoma than did albino mice (with complete lack of pigment), even in the absence of UV radiation.

    #57311
    wpatterson4
    Participant

    Perhaps I’m betraying my pale Celtic heritage, but I really wish that these mutant versions of mc1r had never come into existence in the first place. I don’t know what purpose these changes could have possibly served. At least you can say that the genes underlying sickle-cell disease are good for something. Skin that refuses to tan is good for nothing. It’s a handicap.

    #57312
    Catherine Poole
    Keymaster

    I know, I was cursed with it too and I have brown hair, brown eyes. I had so many sunburns as a child and I loved to swim!! I finally learned to keep a shirt on to protect some of me as this was way before sunscreen was being used and those great new protective swim suits.

    #57313
    wpatterson4
    Participant

    I’m a dish water blond, myself.

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