interesting report on zelboraf intermitent dosing

[Violeta]

http://onlinelibrary.wiley.com/doi/10.1111/bjd.12615/pdf

Just wanted to share with you this recent report about an 85 years patient that is still surviving on intermittent treatment.

my best wishes for all of you.

[Catherine Poole]

That is an interesting story. Our very own Dick had his 4 year anniversary on Zelboraf!

[Violeta]

Catherine Poole wrote:

That is an interesting story. Our very own Dick had his 4 year anniversary on Zelboraf!

Indeed is amazing..

Catherine, is Dick as well on intermittent dosing? .. I am very interested in details.

Is intermittent dosing of Braf inhibitors subject of any clinical trial? Wondering why the discontinuous regime of this medicine is not more tested?

Edit: I read this is more and more seen as an feasible way to overcome the tumor resistance in patients that already acquired it. Could be a big hope for those who progress on inhibitors..

[Dick_K]

I am not on intermittent dosing although I have had a few one week holidays over the past two years due to blood issues.

[Violeta]

Thanks a lot to let me know, Dick. Stay like this, it is extraordinary!

However, I think patient situation in the above article is different than yours..He is not the same lucky. Reading carefully the article I am convinced that if he was going continuously on zelboraf he would get resistance. He simply delayed , because of discontinuation. I am not of course, a specialist, but who knows, maybe is a way to go in case of no choice.

Well… like all of us, always thinking further.

wish you all the best!

[Author]

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