Home Forums Melanoma Diagnosis: Stage IV Interesting research for BRAF Negative Folks

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    Catherine Poole

    It seems they might respond to the MEK inhibitor, which we saw with one of our people here on the forum: http://www.eurekalert.org/pub_releases/2012-07/vumc-ubm071612.php


    2 WT mutations that were found in my tumor samples are:

  • BRAF G466E (from the original BRAF testing done by Kaiser)

    NRAS G12A (from testing done at UCSF).

  • I’ve seen the NRAS one mentioned as a known mutation seen in other patients’ tumors, but so far not the G466 BRAF one.

Catherine Poole

I think this is all very interesting and exciting when we can match a mutation to a therapy!

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