Dear all,
For those of you in Nevada or willing/ able to travel there, I just saw this study
http://clinicaltrials.gov/ct2/show/NCT01565837?term=melanoma&recr=Open&rank=66
It will get you Ipilimumab at the higher concentration of 10mg- on publications before the approval for Ipi, this was the recommended dosis, that was before the 3mg that were in the study filed for approval of the drug- please search this forum, there has been a long discussion about 3 versus 10 mg Ipi before.
Stereotactic radiotherapy allows to administer high doses of radiation to local spots, thereby harming the tumor but not (or much less) the surrounding tissue. Traditionally, Melanoma has been thought to be resistant to radiotherapy but that does not seem to hold true across the board (I personally wished we had made much more use of it as Peter’s tumors responded extremely well to it).
There has been some discussion about synergistic effects of immuno and radiotherapy, so this study looks like a very good set-up.
Bettina