Home Forums Melanoma Diagnosis: Stage IV IPI/PD1 Globally Recruiting

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  • #22372
    Catherine Poole
    Keymaster

    I posted elsewhere, I just found the Checkmate trial as having several locations recruiting globally. This is the PD1 and IPI combination trial, NCT02156804. Go to for locations: https://clinicaltrials.gov/ct2/show/NCT02156804

    #66416
    Mikers
    Participant

    It is not really clear does this require prior treatment with ipi?

    #66417
    Catherine Poole
    Keymaster

    No, the opposite, you need to be IPI naive (or never had it.)

    #66418
    Thomvdv
    Participant

    Am I reading it incorrectly or is it just Nivo you get?

    #66419
    Catherine Poole
    Keymaster

    No, you get both IPI and NIVO. That’s why they call it checkmate (I think) using two immunotherapies at once. It has had promising results in small studies so far. We’ve reported on it elsewhere here.

    #66420
    EvaSara
    Participant

    Catherine, are you sure that you have posted the right link?

    The title of the study in the link is “A Single-Arm, Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) for Subjects With Histologically Confirmed Stage III (Unresectable) or Stage IV Melanoma Progressing Post Prior Treatment Containing an Anti-CTLA4 Monoclonal Antibody (CheckMate 172)” and the intervention only mentions Nivolumab.

    #66421
    Catherine Poole
    Keymaster

    You are correct EvaSara, I apologize. I meant to post this one: https://clinicaltrials.gov/show/NCT02186249 but now I am trying to make sure it is available globally. This is the combo of IPI/PD1. The other is just PD1 for those who have progressed on IPI. Sorry for any confusion I may have caused.

    #66422
    Thomvdv
    Participant

    ok, thank you!

    IPI/PD1 sadly is only USA…

    #66423
    Catherine Poole
    Keymaster

    I’m still double checking with Bristol Myers Squibb and perhaps there is a plan in place to have it. In the meantime I did hear from UZ/Brussel: both nivolumab and pembrolizumab therapy available in our center (UZ Brussel, Brussels, Belgium), (post ipilimumab treatment).

    #66424
    Thomvdv
    Participant

    Keytruda and nivolumab are also available in UZ Leuven, Belgium.

    But when i asked the onc there: no sign of the ipi/nivo as of yet

    #66425
    Thomvdv
    Participant

    Thomvdv wrote:

    Keytruda and nivolumab are also available in UZ Leuven, Belgium.

    But when i asked the onc there: no sign of the ipi/nivo as of yet

    K+N also post ipi so third line

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