Home Forums Melanoma Diagnosis: Stage IV Melanoma and Viagra Link

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  • #22192
    Linda G
    Participant

    Hello again,

    I have been on this forum before and want to know if anyone is aware of the new JAMA article published on April 17, 2014 regarding Viagra use and increased risk of Melanoma. My husband was diagnosed in February with advanced stage IV mucosal melanoma with metastasis to his spine at that time. Since then he has had surgery, radiation, Yervoy and is presently on Pembrolizumab. His most recent scan has shown further advancement of the cancer to in his liver and kidneys with lung nodules also appearing. He has been using Viagra for many years now and as recently as 2 weeks ago. I just came upon this article and want to know if there is any knowledge out there in the community about this and whether this could be affecting his progress with treatment.

    #65540
    CraigG
    Participant

    Yes my spouse found this interesting article on it. I guess I am not allowed to attach a PDF. You should be able to google it.

    Sildenafil Use and Increased Risk of Incident Melanoma in US Men

    A Prospective Cohort Study

    Wen-Qing Li, PhD; Abrar A. Qureshi, MD, MPH; Kathleen C. Robinson, PhD; Jiali Han, PhD

    I also have heart problems, and tadalafil (aka Viagra) was found to be very beneficial to patients with pulmonary hypertension. We all know the other side effects. But this drug, tadalafil, really helped with my general fatigue and lack of energy. Got me back to feeling ‘normal’. Since I have been on 4 other experimental melanoma chemo drugs, it would be difficult to say which drug is causing my new melanomas. Since being on Zelborof, I have seen an uptick in squamous cell and melanomas on skin. My tumor generator is definitely in high gear. I get most of them radiated, due to comfort level. If I think Keytruda is working – I will suggest taking me off tadalafil.

    For me it seems worth the risk.

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