Home Forums Melanoma Diagnosis: Stage IV Merck 3475 side effects

  • This topic is empty.
Viewing 3 posts - 1 through 3 (of 3 total)
  • Author
    Posts
  • #21976
    njreaders
    Participant

    Does aanyone know what the potential side effects of the Merck 3475 drug are? thanks.

    #64404
    Catherine Poole
    Keymaster

    The side effect profile has been very good, meaning very few side effects that are debilitating. Fatigue, rash, nausea have been reported. The one worrisome side effect has been pneumonitis, a lung infection that can be very serious. It has occurred in a small number of patients. Otherwise, this drug is very hopeful.

    #64405
    erinmay22
    Participant

    Ok this is a long one! Sorry… but copied below the side effects listed on the trial paperwork for the MK3475. I’ve been on the trial since Jan 2013. I think my biggest complaint is fatigue…

    Thanks,

    Erin

    Likely:

    – Feeling tired, lack of energy

    – Cough

    – Rash

    – Itching of the skin

    – Frequent or excessive bowel movements

    – Pain in joints

    – Nausea

    Less Likely:

    – Pain in abdomen

    – Headache

    – Pain in a muscle or group of muscles

    – Abnormal laboratory results of liver test by blood that occasionally indicates liver failure, manifesting as yellowing of the skin or whites of the eyes, fatigue, or leg swelling

    – Weakness

    – Constipation

    – Swelling of the lower limbs due to a build-up of fuilds

    – Shortness of breath

    – Loss of appetite

    – Decreased release of thyroid hormone that may manifest as feeling tired, weight gain, feeling cold easily, or bowel movements occurring less often than usual

    – Feeling cold

    – Loss of skin color

    – Vomiting

    – Momentary feeling of whole body warmth possibly accompanied by sweating

    – Night sweats

    – Decrease in red blood cells that may results in feeling tired or short of breath

    – Dizziness

    – Weight loss

    – Pain in the back, arms, or legs

    – Decreased platelets in the blood that may results in bruising or bleeding easily

    – Dry eyes

    – Dry mouth

    – Feeling of pain, pins, and needles, or burning, usually in the fingers or toes

    – Red rash

    – Swelling of the legs

    – Pain or uncomfortable feeling in the belly

    – Sweating excessively

    – Flu or flu-like illness which may include fever, chills, body aches, and feeling tired

    – Change in how you see or change in your eye(s) function

    – Increased release of thyroid hormone which may manifest as anxiety, irritability, or trouble sleeping, weakness, trembling, sweating, feeling uncomfortable in warm weather, fast or uneven heartbeats, feeling tired, weight loss, and frequent or excessive bowel movements.

    Rare but serious:

    – Fever

    – Dehydration

    – Loss of kidney function which may result in swelling of the legs and possibly needing dialysis

    – Decreased white blood cells, red blood cells, and/or platelets which may manifest with fever, feeling cold, infections

    – Increased release of thyroid hormone which may manifest as anxiety, irritability, or trouble sleeping, weakness, trembling, sweating, feeling uncomfortable in warm weather, fast or uneven heartbeats, feeling tired, weight loss, and frequent or excessive bowel movements.

    – Infection throughout the body by a fungus that may manifest as fever, feeling tired, feeling cold, and not responding to most antibiotics

    – Inflammation of the lining around the heart which may manifest as the frequent or excessive watery bowel movements

    – Inflammation of the muscles that may manifest as weakness or pain in the muscles

    – Inflammation of the kidneys causing them not to work as well, which may manifest as swelling of the legs and possibly needing dialysis

    – Inflammation of the pituitary gland, which may manifest as headache, nausea, a sensation of the room spinning around you, changes in behaviour, double vision, or weakness

    – Inflammation of the lungs, manifesting as shortness of breath, and may lead to death

    – Inflammation of the pancreas that may manifest as severe upper abdominal pain that may move to the back, nausea and vomiting that is worsened with eating.

    – Inflammation of the livery that may manifest as yellowing of the skin and whites of the eyes, fever, and belly pain.

Viewing 3 posts - 1 through 3 (of 3 total)
  • The forum ‘Melanoma Diagnosis: Stage IV’ is closed to new topics and replies.