Home Forums Newly Diagnosed Stage III/IV neoplastic cells-HMB45 positive and S-100 negative

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    I was a previously level 3-A (after first diagnosed in November 2010), have taken path of ‘wait and see’ due to being level 3, with regular scans, and seeing dermatologists, with regular scans and check ups…..about year and a half ago have small melanoma appear above left hip (opposite side of original site which was right forearm………have successfully removed………..however due to this second occurance….. specialist — now has me at level lV…………Recently (appx. year later) … I had a scan and spot showed up from my right buttock…..took a biopsy…… Result unfortunately came back–Metastatic malignant melanoma. with following comment:

    The neoplastic cell are HMB45 positive and S-100 negative by immunohistochemical stain. The immunohistochemical profile supports malignant melanoma.

    I have an appointment with specialist late next week, any thoughts, or insights on report received?


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