I’m sorry to your husband and you are going through that. I’ve had a taste of that desperateness at one point with brain mets. Are they planning focused narrow radiation like Gamma Knife or CyberKnife as opposed to whole brain radiation/WBR?
Hopefully Catherine will see this soon because she really knows the ins and outs of PD1 trials. At least some of the BMS nivolumab/anti-pd1 trials accept inactive, treated brain mets after some kind of waiting period to prove the mets are inactive. I believe the patient would typically need to get radiation therapy like your husband is, and then have the brain mets inactive (stable? not sure) for some amount of time. The waiting after treatment might be the weak point of this approach.
There is a “melanoma clinical trial finder” service, I don’t know if it’s wrong to link to another organization’s web site, but I tried it once and it seemed excellent. It’s done by a third-party company, emergingMed: http://www.melanoma.org/learn-more/patient-reference-guide/melanoma%20clinical%20trial%20finder” class=”bbcode_url”>http://www.melanoma.org/learn-more/patient-reference-guide/melanoma%20clinical%20trial%20finder They might find some other alternative to consider besides anti-PD1, although anti-PD1 is certainly at the top of lots of peoples’ lists including my own oncologist.
It has really upsets me and some others in your husband’s situation that a brain met excludes people from treatment. Wouldn’t a treatment’s success or failure be best evaluated under “real world” conditions?
Anyway, good luck and wishing you fast results for your next step.