PD-L1 or PD-1 trial?

[hoping4abreakthru]

My husband Jim has Stage IV melanoma with lung mets and is BRAF -ve. We are just starting to meet with doctors to investigate treatment options. Today we met with a doctor at Princess Margaret Hospital (PMH) in Toronto, who told us that the standard of care for Jim would be chemo followed by ipi. Given the toxicity/relative ineffectiveness of chemo and the low-ish response rate to ipi, we are also considering clinical trials. The PMH doc suggested that Jim may want to participate in the MedImmune clinical trial that combines PD-L1 (MEDI4736) with a MEK inhibitor (trametinib). But I’ve read a lot on-line about PD-1 medications, and there seems to be more evidence out there to support them. My question is whether it makes more sense to try to get Jim into a PD-1 trial or take the spot in the PD-L1 trial. We have another consult at Sunnybrook in Toronto next week to discuss potential clinical trials… so any input is appreciated. Thanks, Cindy

[goldfidler]

Hi Cindy,

Sorry to hear about your husband. I am going through the same right now. Just restaged to Stage IV with positive lung nodules and BRAF negative. Meeting with my oncologist on Monday, Oct 20th to discuss options: IL2, IPI (Yervoy), and MEDI4736 (PDL1) trial. I also plan to discuss the IPI/PDI trials and Keytruda (PD1).

I will post an update next week. My thoughts are with you.

Matt

[Catherine Poole]

Cindy,

As you realize, chemo is not effective for melanoma. The PDL trial is really promising, our board feels as promising as the PD1. I hope this is helpful to you.

[odonoghue80]

Do the trials for PDL1 only work in combination with PD1? Or are there trials of PDL1 on its own?

[Catherine Poole]

I found this one to be listed as a sole agent: NCT01375842 (Genentech) the Medimmune one I could not find listed. Otherwise on http://www.clinicaltrials.gov, I’m seeing it combined with different agents such as zelboraf. Tried to copy and paste but wouldn’t work..

[goldfidler]

here is a link to the information I was given, for what it is worth.

http://clinicaltrials.gov/show/NCT02027961

NCT02027961

[Catherine Poole]

thanks so much for posting, that will be very helpful to others I am sure! We are fortunate to have to PDL therapies out there and I hope we get results soon.

[goldfidler]

Hi Cindi,

Just letting you know that I will be starting the MEDI4736 trial on 11/3. I posted a lot of info about my decision process in another thread. I plan to post my progress as best I can.

I wish you the best of luck in your decision process. We are here to support you.

Best Regards,

Matt

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