This is great news Catherine and thanks for posting it.
Yeah, the trial size is relatively small and at one location, but Merk and Yale are thinking about it and I suspect there may be some data which warranted further investigation . Good news.
No exclusions for any number of prior systemic treatments but they need to have been completed at least 2 weeks earlier. This is good but, what caught my attention, was that there were no specific exclusions prior IPI or Braf/Mek. This could be very important indeed.
Also, also, you can have up to 10 mg of predisone equivalent per day.
Yes, it’s a measurable size that they can use to get accurate measurements. The lower limit is set by the resolution capability of MRI and I imagine the upper limit set for safety. The “target” mets must also be in an area of the brain that is judged to be tolerant of any growth that may occurr during treatment. Other mets can be zapped with radiation or surgically removed.