Home Forums Melanoma: Stage III Possible disease progression

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  • #23429
    Tracyyy123
    Participant

    Hi, my mother had a CT today which showed enlarged hilar and mediastinal nodes in her chest and the oncologist immediately sent her for a PET/CT on Thursday. I was hoping so much for stable or clear results, now I am worried that the treatment has stopped working. She is on a trial Dab/Tram + spartalizumab immunotherapy /or placebo. In the end of summer she had pneumonitits, is it possible that those nodes are inflamed due to some infection….I really hope so.

    #70810
    Catherine Poole
    Keymaster

    So sorry to her of this complication. Hopefully, if it is something to worry about it, you’ve caught it early! That is the beauty of clinical trials, the close monitoring of patients. Please let us know what you find out as I am also interested in this trial. Hang in there..

    #70811
    Tracyyy123
    Participant

    Hi Catherine,

    The results are in, and I am a bit relieved because I think they are more positive than negative:

    “Increased metabolic activity in the area of mediastinal lymph nodes which most probably is result of pseudoprogression or sarcoidosis /as a side effect from treatment/, but possible disease progression could not be completely excluded.”

    There is still some uncertainty, but I am very positive that it is a side effect of treatment. Now I am more convinced she is getting spartalizumab, not the placebo.

    #70812
    Catherine Poole
    Keymaster

    I hope the mostly good news continues!

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