Yeah, that was my take on it too. The mutations are so rapid, a sort of “natural selection” process takes place. The ones that survive can multiply. kinda like killing flies in the barn. If you use only one agent and don’t get them all, they can multiply over time so it’s best to use multiple agents in combination and sequence to keep them under control. This idea might explain why the combos and sequences can work so well with melanoma.
Lot’s of good work going on now and I’m sure this investigation will lead to others as well.
This is not related but does anyone know the wisdom behind using the 10mg/kg dose of adjuvant treatment of Ipi. If I had been offered that I would worry that I would develop toxicities that would prevent further use if you progressed to Stage 4. I’m not talking about me specifically just a general question.