Steven, I’ve been on the combo since August. My side effects have been mild and very manageable –some joint pain, foot pain, acne. The most common side effect and the one to watch is high fever (which I haven’t head). Best of luck.
I am guessing you are mentioning the GSK braf/mek? So as we’ve discussed before, fevers seem to be the most complained about side effect and you can sometimes offset them with prophylactic advil/tylenol. Be sure to discuss with your doctor. Also, you might want to look at the Novartis trial that has a combo that is promising and doesn’t have fevers.
Steven, I work full time (knowledge/office work) and have not missed a day of work due to side effects. At worst, I may have taken Advil once or twice. As for exercise, among other things, I live in the city and walk to work (35 min) everyday if that helps. Happy to answer any other questions.