Home Forums Melanoma Diagnosis: Stage IV Taf/Mek Combo

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    My husband (Stage IV) has been on the taf/mek combo for a couple months. We just got scans yesterday and while the tumors shrunk dramatically, two “new” small tumors showed up on this scan in addition to one small one on hip and arm. Has anyone had a “mixed” response on the combo? Our onc thinks maybe these new tumors showed up in the 2.5 weeks after the first scan and before we started the combo. Thanks!

    Catherine Poole

    It is always difficult to determine the growth of tumors and when it occurred. My hope is it did happen prior to the therapy. I would keep in the mind some plan B’s in case there is further progression. The immunotherapies would be next in line, IPI to qualify for PD1, or the IPI/PD1 combo trial that may be recruiting. There is an open access program as well which I will research to see if it is recruiting and it appears to be, find out more: https://clinicaltrials.gov/show/NCT02186249

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