Home Forums Melanoma Diagnosis: Stage IV Trial to consider.. for braf positive

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  • #21794
    Catherine Poole
    Keymaster

    This is a BRAF/MEK combo by Novartis which is said to be quite promising with less side effects, you must be BRAF positive and BRAF treatment naive: http://clinicaltrials.gov/ct2/results?term=+NCT01909453.&Search=Search

    #63515
    NYKaren
    Participant

    Hi Catharine, I posted about a Pan-RAF trial about 5 or 6 posts down. Didn’t get any replies… Do you know anything about it? I’m on the combo, and while it seems to be keeping my brain clear. (MRI on Tuesday–but I’m not exhibiting any tell-tale signs) my skin is still a mess–maybe it only works on the inside, lol.

    I was asking about this trial because Dr. Pavlick mentioned it as a possible alternative if the combo fails and until PD1 is approved. The # is MLN2480 on clinicaltrials.gov.

    Thanks,

    Karen

    #63516
    Catherine Poole
    Keymaster

    Karen, do you have the NCT number? If this is phase one, we know very little and I’ve not heard of it before. But I’m happy to research if you list that number for me. Thanks and wishing you well!

    #63517
    kylez
    Participant

    Pretty sure it is NCT01425008. The drug MLN2480 is described as an oral PAN-RAF inhibitor here, http://meetinglibrary.asco.org/content/109770-132” class=”bbcode_url”>http://meetinglibrary.asco.org/content/109770-132.

    #63518
    NYKaren
    Participant

    Thanks, Kyle.

    I did post this last night, but maybe not…

    Yes that is correct trial. Have you heard anything about it?

    Karen

    #63519
    kylez
    Participant

    Karen, I have heard nothing at all. But I hope Catherine can find some information on it for you.

    #63520
    Catherine Poole
    Keymaster

    Looks like a very early phase 1 and there’s no way to know its promise until it reaches later phases. I haven’t heard anything about it otherwise.

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