My husband has been on Zelboraf and we are so grateful that 13 months later, it is still working:). So, lots of experience with side effects. The question is….he’s always had diarrea with Z. It’s worse some days than others, but always there. He never complains and hates to take any more medicine than he has to. Has anyone else had this issue? Any OTC meds? Any foods that help or make it worse? We know cheese and dairy make it worse, but haven’t figured out foods that makes it better. The doctor isn’t concerned, and he really isn’t either, but it’s just one of those constant things that wears on him.