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Viewing 15 posts - 1 through 15 (of 48 total)
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  • in reply to: Checkpoint blockage #67323
    Steven
    Participant

    Congratulations on your son’s wedding!

    Sorry if I was presumptuous. I just thought you might have all the recent trial results handy.

    in reply to: MIF at ASCO! #67192
    Steven
    Participant

    I think the 25.1 refers to overall survival:

    The final analysis included the 423 patients enrolled in COMBI-d and showed that the combination of Tafinlar and Mekinist achieved a statistically significant overall survival (OS) benefit compared to Tafinlar monotherapy (median of 25.1 months vs 18.7 months)1. The analysis for the combination also showed median progression-free survival (PFS) of 11.0 months, overall response rate (ORR) of 69%, and median duration of response (DoR) of 12.9 months1

    http://www.news-medical.net/news/20150601/Combination-of-Mekinist-and-Tafinlar-drugs-improves-outcome-in-patients-with-metastatic-melanoma.aspx

    in reply to: Father Diagnosed – Refuses Treatment #66920
    Steven
    Participant

    I am braf +. Find out if your Dad is.

    If he is there is a treatment (Mekinist + Tafinlar) that is a pill(s) taken at home. Sometimes there are few to any side effects. Once my oncologist got me on the right dose I have had none.

    in reply to: IPI vs. NIVO Trial opening in March first in Europe! #66660
    Steven
    Participant

    I thought it was clear that PD1 has better stats than Ipi, no?

    in reply to: My TAFINLAR (braf) + MEK dosage story #65240
    Steven
    Participant

    Hello all. Happy Thanksgiving.

    This is an update to my original post from 3 months ago (see below or above). I have since had:

    October brain MRI – clean

    November chest – stable. 5×5 mm, 8×3 mm, 4×2 mm.

    I am still on a reduced, every other day dosage. No side effects.

    My oncologist says if I remain stable for another 3-6 months she may recommend stopping as she has others who have stopped after prolonged stability with continued stability, and that she believes if needed the drugs can be restarted.

    Best wishes to all.

    Steven

    in reply to: My experience with Merck’s anti-PD1 (Keytruda) since May #65763
    Steven
    Participant

    Hi Jonathan

    So happy to hear from you, and that you are doing well!!!!

    Steven

    in reply to: My TAFINLAR (braf) + MEK dosage story #65239
    Steven
    Participant

    Thank you my friend. I am definitely proof of the side effects. I am on the combo for almost 8 months so still not past the average for effectiveness I do not think. Hopefully soon!

    in reply to: My TAFINLAR (braf) + MEK dosage story #65237
    Steven
    Participant

    Folks in the trial might be following the protocol for that trial.

    My point in posting is that there are different paths to effectiveness. As many say on this board, we are all individuals. For me, at least for now, the every other day dosing of a lower than “normal” amount is doing it for me, and may for others.

    in reply to: Update on Jonathan #64580
    Steven
    Participant

    Hi Jonathan

    Great to hear from you. You rock!

    Your advice is so excellent. Even when healthy, pain can change our mood. Thank you for pointing it out.

    Steven

    in reply to: Pd1 News #64894
    Steven
    Participant

    Hi Catherine – is the reason the FDA is requiring failing Ipi first because they are not convinced that PD1 is better than Ipi?

    in reply to: Check out our new patient video #64720
    Steven
    Participant

    Hi Catherine – great job on the video!

    in reply to: Update on Jonathan #64561
    Steven
    Participant

    Hi Jonathan

    Best wishes for quick healing. Here’s to Merck and Yale doing their parts!

    Steven

    in reply to: Expanded Access Program With Nivolumab for Subjects #64432
    Steven
    Participant

    Is it possible that the final FDA approval will also have the requirement about previous ipi use? Are there any other drugs in the world that require previous use of another drug?

    in reply to: How is Jonathan? #63749
    Steven
    Participant

    Hi Jonathan

    So happy to hear you are well.

    I am feeling fine. I have had 2 gamma knife’s and am now on Braf/Mek. A week and a halk in and no side effects so far. I’m sending good vibes to you from NY daily.

    Steven

    in reply to: Starting BRAF/MEK #63550
    Steven
    Participant

    When you say live in the city do you mean NYC? If so, where are you being treated?

Viewing 15 posts - 1 through 15 (of 48 total)