Forum Replies Created
Congratulations on your son’s wedding!
Sorry if I was presumptuous. I just thought you might have all the recent trial results handy.
I think the 25.1 refers to overall survival:
The final analysis included the 423 patients enrolled in COMBI-d and showed that the combination of Tafinlar and Mekinist achieved a statistically significant overall survival (OS) benefit compared to Tafinlar monotherapy (median of 25.1 months vs 18.7 months)1. The analysis for the combination also showed median progression-free survival (PFS) of 11.0 months, overall response rate (ORR) of 69%, and median duration of response (DoR) of 12.9 months1
I am braf +. Find out if your Dad is.
If he is there is a treatment (Mekinist + Tafinlar) that is a pill(s) taken at home. Sometimes there are few to any side effects. Once my oncologist got me on the right dose I have had none.March 3, 2015 at 2:45 am in reply to: IPI vs. NIVO Trial opening in March first in Europe! #66660
I thought it was clear that PD1 has better stats than Ipi, no? Hello all. Happy Thanksgiving.
This is an update to my original post from 3 months ago (see below or above). I have since had:
October brain MRI – clean
November chest – stable. 5×5 mm, 8×3 mm, 4×2 mm.
I am still on a reduced, every other day dosage. No side effects.
My oncologist says if I remain stable for another 3-6 months she may recommend stopping as she has others who have stopped after prolonged stability with continued stability, and that she believes if needed the drugs can be restarted.
Best wishes to all.
StevenNovember 2, 2014 at 9:36 pm in reply to: My experience with Merck’s anti-PD1 (Keytruda) since May #65763
So happy to hear from you, and that you are doing well!!!!
Thank you my friend. I am definitely proof of the side effects. I am on the combo for almost 8 months so still not past the average for effectiveness I do not think. Hopefully soon! Folks in the trial might be following the protocol for that trial.
My point in posting is that there are different paths to effectiveness. As many say on this board, we are all individuals. For me, at least for now, the every other day dosing of a lower than “normal” amount is doing it for me, and may for others.
Great to hear from you. You rock!
Your advice is so excellent. Even when healthy, pain can change our mood. Thank you for pointing it out.
Hi Catherine – is the reason the FDA is requiring failing Ipi first because they are not convinced that PD1 is better than Ipi? Hi Catherine – great job on the video! Hi Jonathan
Best wishes for quick healing. Here’s to Merck and Yale doing their parts!
StevenMay 23, 2014 at 1:37 am in reply to: Expanded Access Program With Nivolumab for Subjects #64432
Is it possible that the final FDA approval will also have the requirement about previous ipi use? Are there any other drugs in the world that require previous use of another drug? Hi Jonathan
So happy to hear you are well.
I am feeling fine. I have had 2 gamma knife’s and am now on Braf/Mek. A week and a halk in and no side effects so far. I’m sending good vibes to you from NY daily.
When you say live in the city do you mean NYC? If so, where are you being treated?